What is Sodium Fluoride?
Sodium fluoride (NaF) is an inorganic compound with the formula NaF. It is used in trace amounts of fluoridation of drinking water, toothpaste, metallurgy, flux, pesticides and rat poisons. It is a colorless or white solid that is easily soluble in water. It is a common source of fluoride in pharmaceutical manufacturing and is used to prevent dental caries.
The NaF mineral form villiaumite is moderately rare. Plutonic nepheline is known to exist in syenite rocks. Sodium fluoride, which is produced in a laboratory environment other than that found in nature, should be determined by experts and meticulously depending on the purpose of use. It is a poisonous and potentially harmful substance.
In 2017, it was the 247th most commonly prescribed drug in the United States, with over one million prescriptions.
How is Sodium Fluoride produced?
NaF is prepared by neutralizing hydrofluoric acid or hexafluorosilicic acid (H2SiF6), the by-products of the reaction of fluoropatite (Ca5(PO4)3F) from phosphate rock during superphosphate fertilizer production. Neutralizing agents include sodium hydroxide and sodium carbonate. Alcohols are sometimes used to precipitate NaF:
HF + NaOH → NaF + H2HE
From solutions containing HF, sodium fluoride precipitates as the bifluoride salt sodium bifluoride (NaHF2). Heating the latter releases HF and yields NaF.
F + NaF ⇌ NaHF2
What does Sodium Fluoride look like?
A colorless and white solid
What is the molecular formula of Sodium Fluoride?
Molecular Formula: NaF
In which sectors is Sodium Fluoride used?
- Mouth and dental health
- osteoporosis supplement
- medical imaging
- Organic synthesis in chemistry
- Fluorocarbon production
What are the uses (processes) of Sodium Fluoride?
- Fluoride salts are often added to common drinking water (and certain food products in some countries) to maintain dental health. Fluoride increases the durability of teeth by the formation of florapatite, a naturally occurring component of tooth enamel. Hexafluorosilicic acid (H2SiF6) and salt sodium hexafluorosilicate (Na2SiF6) are the more commonly used additives in the United States, although sodium fluoride is used to fluoride water and is the standard by which other water fluorinating compounds are measured.
- Fluoride supplementation has been extensively studied for the treatment of postmenopausal osteoporosis. This supplement does not appear to be effective; Although sodium fluoride increases bone density, it does not reduce the risk of fracture.
- In medical imaging, fluorine-18-labeled sodium fluoride (USP, sodium fluoride F18) is one of the earliest tracers used in positron emission tomography (PET), used since the 1960s. Compared to traditional bone scintigraphy performed with gamma cameras or SPECT systems, PET offers greater sensitivity and spatial resolution. Fluor-18 has a half-life of 110 minutes, which requires it to be used immediately after manufacture; this logistical limitation has hindered its adoption in the face of more suitable technetium-99m-labeled radiopharmaceuticals. However, fluorine-18 is generally considered a superior radiopharmaceutical for skeletal imaging. In particular, it has a high and rapid bone uptake accompanied by very rapid blood clearance, enabling a high bone-to-background ratio in a short time. In addition, the annihilation photons produced by the decay of 18F have a high energy of 511-keV compared to the 140-keV photons of 99mTc.
- Sodium fluoride has a variety of specialty chemical applications in synthesis and extractive metallurgy. Reacts with electrophilic chlorides, including acid chloride, sulfur chloride and phosphorus chloride. Like other fluorides, sodium fluoride finds use in desililation in organic synthesis.
- Sodium fluoride can be used to produce fluorocarbons via the Finkelstein reaction; this process has the advantage of being simple if performed on a small scale, but is rarely used on an industrial scale due to the availability of more effective techniques (eg Electrofluorination, Fowler process).
- Sodium fluoride is used as a cleaning agent.
- Sodium fluoride is used in rat and insect poisons.
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